Although not specifically approved by the FDA for the management of nausea and vomiting during pregnancy, ondansetron is now commonly used during pregnancy.
Is ondansetron safe during first trimester?
A new study from Brigham and Women’s Hospital finds that pregnant women taking the common anti-nausea medication ondansetron during the first trimester have no increased risk of cardiac malformations and only a slight increased risk of oral clefts.
Can ondansetron cause miscarriage?
Currently, no scientific evidence has linked the anti-nausea drug Zofran, frequently prescribed “off-label” for morning sickness, to an increased risk of miscarriage.
Does ondansetron cause birth defects?
Taking Ondansetron During Pregnancy Does Not Appear to Increase Risk For Birth Defects.
How often can you take ondansetron while pregnant?
The dose of Zofran for hyperemesis gravidarum requiring hospitalization is a maximum of 10 milligrams via intravenous therapy (IV) every 8 hours. More typical pregnancy nausea is managed by a much lower oral dose — 4 to 8 mg every 8 hours.
What nausea medicine is safe while pregnant?
In fact, the FDA has approved a prescription medication for use during pregnancy that is a combination of Vitamin B6 and Unisom. It is called Diclegis. This is the only FDA approved medication for treating nausea and vomiting during pregnancy.
What pregnancy category is ondansetron?
US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Does ondansetron cross the placenta?
Based on the findings of our analysis, ondansetron dosing does not need to be altered in pregnancy, and it readily crosses the placenta. However, a dosage adjustment is required in neonates because of its longer half-life, which is likely to be due to reduced clearance.
Does ondansetron cause cleft palate?
Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy. Recent epidemiological studies suggest exposure to ondansetron during the first trimester of pregnancy is associated with a small increased risk of the baby having a cleft lip and/or cleft palate.
What kind of birth defects does Zofran cause?
Zofran was found to double the risk of heart defects including atrial and ventricular septal (“hole in the heart”) defects and increased the overall risk of birth defects by 30% in one study. Another study found Zofran was linked with a 237% risk of cleft palate defects.
How quickly does Zofran work?
Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran’s effects can last 8 to 12 hours.